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KMID : 0604520110370020171
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 2 p.171 ~ p.176
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Inhibitory Effects of Serotonin Derivatives on Adipogenesis
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Jung Eun-Sun
Kim Seung-Beom
Kim Moo-Han
Shin Seong-Woo
Lee Jong-Sung
Park Deok-Hoon
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Abstract
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N-feruloylserotonin (FS) and N-(pcoumaroyl) serotonin (CS), serotonin derivatives, which have been isolated as major and unique phenolics of safflower seed extract (SSE), are member of hydroxycinnamic acid amides and are implicated in the defense against pathogen infection and insect feeding. In this study, we evaluate inhibitory effects of N-(p-Coumaroyl)serotonin and N-Feruloylserotonin on adipogenesis using oil-red O staining, triglyceride and GPDH activity. we found that while serotonin itself did not suppress differentiation of preadipocytes into adipocytes, N-(p-Coumaroyl)serotonin and N-Feruloylserotonin inhibited the differentiation of preadipocytes into adipocytes in a concentration-dependent manner. In addition, they showed antioxidant effects in DPPH assay. Taken together, these results show that N-feruloylserotonin (FS) and N-(pcoumaroyl) serotonin (CS) suppress differentiation of preadipocytes, suggesting the possibility that these serotonin derivatives can be utilized as an anti-obesity agent.
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KEYWORD
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serotonin derivatives, anti-obesity, adipogenesis, GPDH, triglyceride
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